Vasorelaxation Effect of Estrone Derivate EA204 in Rabbit Aorta
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منابع مشابه
Induction of Vasorelaxation in Isolated Rabbit Aorta by Epimedium Brevicornum Maxim Leaf Extracts
The vasorelaxant effect of Epimedium brevicornum Maxim (Berberidaceae) (EB) was studied in isolated rabbit thoracic aorta. Results showed that water extract of EB (EB-W) concentration-dependently antagonized phenylephrine (PE)-induced vasoconstriction at the concentrations ranging from 0.001 to 1 mg/mL with an EC50 of 12.4 ± 1.5 μg/mL. EB-W evoked vasorelaxation was significantly, however, not ...
متن کاملAge-related decrease in 15-lipoxygenase contributes to reduced vasorelaxation in rabbit aorta.
Rabbit 15-lipoxygenase-1 (15-LO-1) oxygenates arachidonic acid (AA) into 15-hydroperoxyeicosatetraenoic acid, which is then converted to the vasodilatory 15-hydroxy-11,12-epoxyeicosatrienoic acid (HEETA) and 11,12,15-trihydroxyeicosatrienoic acid (THETA). We studied the age-dependent expression of the 15-LO-1 in rabbit aorta and its effects on the synthesis of THETA, HEETA, and vasoactivity. Ao...
متن کاملReticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta.
OBJECTIVE Aortic 15-lipoxygenase (15-LO) metabolizes arachidonic acid (AA) to 15-hydroperoxyeicosatetraenoic acid, which is then converted to the vasodilators 15-hydroxy-11,12-epoxyeicosatrienoic acid and 11,12,15-trihydroxyeicosatrienoic acid. These metabolites contribute to endothelium-dependent relaxations of rabbit aorta to AA and acetylcholine. We investigated the identity of rabbit aortic...
متن کاملEffect of Anastomotic Method on Intimal Hyperplasia in Rabbit Aorta
Purpose: The clinical advantages of end-to-end (ETE) anastomosis have not been clear despite its biomechanical advantage over end-to-side (ETS) anastomosis. We compared the histomorphometric features of intimal remodeling after ETE and ETS anastomosis in a rabbit aortic bypass model. Methods: Thirty-two bypass operations, 16 with ETS and 16 with ETE anastomoses, were performed using aortic allo...
متن کاملRabbit Aorta
We previously showed by qualitative en face autoradiography that after 24 hours of circulation, I-labeled low density lipoprotein (LDL) injected in tracer amounts accumulated focally at the edges of regenerating endothelial islands in the balloon catheter-deendothelialized aorta of the normocholesterolemic rabbit In the present study with the same animal model, we have used quantitative autorad...
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ژورنال
عنوان ژورنال: Scientifica
سال: 2016
ISSN: 2090-908X
DOI: 10.1155/2016/7405797